Structure of PDB 4u4s Chain A

Receptor sequence
>4u4sA (length=256) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKLKNK
WWYDEC
3D structure
PDB4u4s Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3C1 A P494 S729 K730 G731 P102 S214 K215 G216 MOAD: Kd=1200uM
PDBbind-CN: -logKd/Ki=2.92,Kd=1200uM
BS02 GLU A Y450 L479 T480 R485 G653 S654 T655 E705 Y58 L87 T88 R93 G138 S139 T140 E190
BS03 3C1 A P494 F495 M496 P102 F103 M104 MOAD: Kd=1200uM
PDBbind-CN: -logKd/Ki=2.92,Kd=1200uM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4u4s, PDBe:4u4s, PDBj:4u4s
PDBsum4u4s
PubMed25375781
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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