Structure of PDB 4u43 Chain A

Receptor sequence
>4u43A (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE
EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSI
TDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTE
NAEVKLVDFGVNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAI
EMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNY
MQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK
3D structure
PDB4u43 Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.
ChainA
Resolution2.18 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D153 K155 Q157 N158 D171 T191
Catalytic site (residue number reindexed from 1) D140 K142 Q144 N145 D158 T167
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3D8 A V31 V39 A52 C108 L160 V170 D171 V18 V26 A39 C95 L147 V157 D158 MOAD: Kd=48uM
PDBbind-CN: -logKd/Ki=4.32,Kd=48uM
BindingDB: Kd=48000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4u43, PDBe:4u43, PDBj:4u43
PDBsum4u43
PubMed25139565
UniProtO95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 (Gene Name=MAP4K4)

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