Structure of PDB 4u42 Chain A

Receptor sequence
>4u42A (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE
IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITD
LVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENA
EVKLVDFGTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAE
GAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRP
STEQLLKHPFIRDQPNERQVRIQLKDHIDRTR
3D structure
PDB4u42 Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures
ChainA
Resolution2.504 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D153 K155 Q157 N158 D171 T191
Catalytic site (residue number reindexed from 1) D138 K140 Q142 N143 D156 T163
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3C8 A Y36 V39 A52 K54 L103 M105 E106 F107 C108 L160 V170 Y21 V24 A37 K39 L88 M90 E91 F92 C93 L145 V155 BindingDB: IC50=6.20nM,Ki=10.7nM
BS02 MG A S77 H78 H79 R80 I82 S62 H63 H64 R65 I67
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4u42, PDBe:4u42, PDBj:4u42
PDBsum4u42
PubMed
UniProtO95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 (Gene Name=MAP4K4)

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