Structure of PDB 4u3j Chain A

Receptor sequence
>4u3jA (length=431) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MREVISINVGQAGCQIGNACWELYSLEHGIKPDGHLEDGLSKPKGGEEGF
STFFHETGYGKFVPRAIYVDLEPNVIDEVRNGPYKDLFHPEQLISGKEDA
ANNYARGHYTVGREILGDVLDRIRKLADQCDGLQGFLFTHSLGGGTGSGL
GSLLLEELSAEYGKKSKLEFAVYPAPQVSTSVVEPYNTVLTTHTTLEHAD
CTFMVDNEAIYDMCKRNLDIPRPSFANLNNLIAQVVSSVTASLRFDGSLN
VDLNEFQTNLVPYPRIHFPLVSYSPVLSKSSVSEITNACFEPGNQMVKCD
PRDGKYMATCLLYRGDVVTRDVQRAVEQVKNKKTVQLVDWCPTGFKIGIC
YEPPTATPNSQLATVDRAVCMLSNTTSIAEAWKRIDRKFDLMYAKRAFVH
WYVGEGMEEGEFTEAREDLAALERDYIEVGA
3D structure
PDB4u3j A tethered delivery mechanism explains the catalytic action of a microtubule polymerase.
ChainA
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A G10 Q11 A12 Q15 N102 S141 G144 G145 T146 G147 V178 T180 E184 N207 F225 N229 G10 Q11 A12 Q15 N102 S141 G144 G145 T146 G147 V178 T180 E184 N207 F225 N229
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0000280 nuclear division
GO:0007010 cytoskeleton organization
GO:0007017 microtubule-based process
GO:0030473 nuclear migration along microtubule
GO:0045143 homologous chromosome segregation
GO:0098863 nuclear migration by microtubule mediated pushing forces
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0034399 nuclear periphery
GO:0045298 tubulin complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4u3j, PDBe:4u3j, PDBj:4u3j
PDBsum4u3j
PubMed25097237
UniProtP09733|TBA1_YEAST Tubulin alpha-1 chain (Gene Name=TUB1)

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