Structure of PDB 4u22 Chain A

Receptor sequence
>4u22A (length=262) Species: 10116 (Rattus norvegicus) [Search protein sequence]
ANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKY
KLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVID
FSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK
IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIE
QRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLK
NKWWYDKGECGS
3D structure
PDB4u22 Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
ChainA
Resolution1.4409 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FWD A Y61 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 Y60 L89 T90 R95 L137 G140 S141 T142 L191 E192 M195 BindingDB: Ki=4nM,EC50=460nM
BS02 FWF A I92 P105 S108 S217 K218 L239 S242 I91 P104 S107 S216 K217 L238 S241
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4u22, PDBe:4u22, PDBj:4u22
PDBsum4u22
PubMed25109876
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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