Structure of PDB 4u01 Chain A

Receptor sequence
>4u01A (length=182) Species: 333284 (Hepatitis C virus (isolate Con1)) [Search protein sequence]
APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNG
VCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHA
VGIFRAAVCTRGVAKAVDFVPVESMETTMRAS
3D structure
PDB4u01 Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H57 D81 G137 S139
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T4 A5 Y6 S7 Q8 T10 R11 C16 S20 E32 V33 Q34 V35 V36 S37 K62 T63 A65 T4 A5 Y6 S7 Q8 T10 R11 C16 S20 E32 V33 Q34 V35 V36 S37 K62 T63 A65
BS02 39W A F43 H57 D79 D81 V132 K136 G137 S139 F154 R155 A156 A157 F43 H57 D79 D81 V132 K136 G137 S139 F154 R155 A156 A157 PDBbind-CN: -logKd/Ki=8.46,IC50=0.0035uM
BS03 ZN A C97 C99 C145 C97 C99 C145
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:4u01, PDBe:4u01, PDBj:4u01
PDBsum4u01
PubMed26410074
UniProtQ9WMX2|POLG_HCVCO Genome polyprotein

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