Structure of PDB 4tz6 Chain A

Receptor sequence

>4tz6A (length=504) Species: 559292 (Saccharomyces cerevisiae S288C)

SKLIHVPKEEVTLDSLLEEGVLDKEIHKAITRMEFPGLTPVQQKTIKPIL
SSEDHDVIARAKTGTGKTFAFLIPIFQHLINTKFDSQYMVKAVIVAPTRD
LALQIEAEVKKIHDMNYGLKKYACVSLVGGTDFRAAMNKMNKLRPNIVIA
TPGRLIDVLEKYSNKFFRFVDYKVLDEADRLLEIGFRDDLETISGILNEK
NSKSADNIKTLLFSATLDDKVQKLANNIMNKKECLFLDTVDKNEPEAHER
IDQSVVISEKFANSIFAAVEHIKKQIKERDSNYKAIIFAPTVKFTSFLCS
ILKNEFKKDLPILEFHGKITQNKRTSLVKRFKKDESGILVCTDVGARGMD
FPNVHEVLQIGVPSELANYIHRIGRTARSGKEGSSVLFICKDELPFVREL
EDAKNIVIAKQEKYEPSEEIKSEVLEAVTEEPEDISDIVISLISSYRSCI
KEYRFSERRILPEIASTYGVLLNDPQLKIPVSRRFLDKLGLSRSPIGKAM
FEIR

3D structure

• PDB: 4tz6 Molecular insights into RNA and DNA helicase evolution from the determinants of specificity for a DEAD-box RNA helicase.
• Chain: A
• Resolution: 3.209 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	P188 T189 R190 G220 G221 T242 G244 R245 D248 R271 F277 T382 V383 H407 G408 R415 T433 S535 S536	P97 T98 R99 G129 G130 T151 G153 R154 D157 R180 F186 T291 V292 H316 G317 R324 T342 S444 S445
BS02	BEF	A	K158 E268 R466 R469	K67 E177 R375 R378
BS03	UDP	A	F126 Q133 G155 G157 K158 T159 R469 S470	F35 Q42 G64 G66 K67 T68 R378 S379

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:4tz6, PDBe:4tz6, PDBj:4tz6
• PDBsum: 4tz6
• PubMed: 25497230
• UniProt: P15424|MS116_YEAST ATP-dependent RNA helicase MSS116, mitochondrial (Gene Name=MSS116)