Structure of PDB 4tyj Chain A

Receptor sequence
>4tyjA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
MGSAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGGQVVRAEAFGMDPARPD
QASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGP
LYVIVECAAKGNLREFLRARRPPLSFPVLVSCAYQVARGMQYLESRKCIH
RDLAARNVLVTEDNVMKIADFGLARLPVKWMAPEALFDRVYTHQSDVWSF
GILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMREC
WHAAPSQRPTFKQLVEALDKVLLAVSEE
3D structure
PDB4tyj Structural analysis of the human fibroblast growth factor receptor 4 kinase.
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D612 A614 R616 N617 D630
Catalytic site (residue number reindexed from 1) D152 A154 R156 N157 D170
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LI A A501 K503 E520 M524 V550 A553 I609 H610 L619 I628 A629 D630 F631 A56 K58 E75 M79 V105 A108 I149 H150 L159 I168 A169 D170 F171 BindingDB: IC50=8.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4tyj, PDBe:4tyj, PDBj:4tyj
PDBsum4tyj
PubMed25219510
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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