Structure of PDB 4tyi Chain A

Receptor sequence
>4tyiA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
SAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPD
QASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGP
LYVIVECAAKGNLREFLRARRPPPLSFPVLVSCAYQVARGMQYLESRKCI
HRDLAARNVLVTEDNVMKIADFGLARGLPVKWMAPEALFDRVYTHQSDVW
SFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMR
ECWHAAPSQRPTFKQLVEALDKVLLAV
3D structure
PDB4tyi Structural analysis of the human fibroblast growth factor receptor 4 kinase.
ChainA
Resolution3.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D612 A614 R616 N617 D630
Catalytic site (residue number reindexed from 1) D153 A155 R157 N158 D171
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38O A I534 V550 A553 G556 L619 I89 V105 A108 G111 L160
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4tyi, PDBe:4tyi, PDBj:4tyi
PDBsum4tyi
PubMed25219510
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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