Structure of PDB 4txy Chain A

Receptor sequence
>4txyA (length=375) Species: 243277 (Vibrio cholerae O1 biovar El Tor str. N16961) [Search protein sequence]
TWNFHQYYTNRNDGLMGKLVLTDEEKNNLKALRKIIRLRTRDVFEEAKGI
AKAVKKSALTFEIIQEKVSTTQIKHLSDSEQREVAKLIYEMDDDARDEFL
GLTPRFWTQGSFQYDTLNRPFQPGQEMDIDDGTYMPMPIIGHSLLILLVD
ASLKSLVAENHGWKFEAKQTCGRIKIEAEKTHIDVPMYAIPKDEFQKKQI
AELDSENVNLALREGDRKWINSDPKIVEDWFNDSCIRIGKHLRKVCRFMK
AWRDAQWDVGGPSSISLMAATVNILDSVAHDASDLGETMKIIAKHLPSEF
ARGVESPDSTDEKPLFPPSYKHGPREMDIMSKLERLPEILSSAESADSKS
EALKKINMAFGNRVTNSELIVLAKA
3D structure
PDB4txy Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity.
ChainA
Resolution3.0001 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D132 D134 D194 D128 D130 D184
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0052621 diguanylate cyclase activity
GO:0140701 3',3'-cyclic GMP-AMP synthase activity
Biological Process
GO:0009117 nucleotide metabolic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0050922 negative regulation of chemotaxis
GO:0051607 defense response to virus
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4txy, PDBe:4txy, PDBj:4txy
PDBsum4txy
PubMed25131990
UniProtQ9KVG7|DNCV_VIBCH Cyclic GMP-AMP synthase (Gene Name=dncV)

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