Structure of PDB 4txi Chain A

Receptor sequence
>4txiA (length=583) Species: 10090 (Mus musculus) [Search protein sequence]
NPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNY
WSAKSLWAKLDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLG
ARVVLVEKRIKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISI
RQLQLLLLKVALLLGVEIHWGVKFTGLQPPPRKGSGWRAQLQPNPPAQLA
SYEFDVLISAAGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPE
ISGVARIYNQKFFQSLLKATGIDLENIVYYKDETHYFVMTAKKQCLLRLG
VLRQDLSETDQLLGKANVVPEALQRFARAAADFATHGKLGKLEFAQDARG
RPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVA
RGFLAAFDAAWMVKRWAEGAGPLEVLAERESLYQLLSQTSPENMHRNVAQ
YGLDPATRYPNLNLRAVTPNQVQDLYDMMDSAGTEELLHWCQEQTAGFPG
VHVTDFSSSWADGLALCALVHHLQPGLLQGMGALEATTWALRVAEHELGI
TPVLSAQAVMAGSDPLGLIAYLSHFHSAFKNTS
3D structure
PDB4txi Modulation of MICAL Monooxygenase Activity by its Calponin Homology Domain: Structural and Mechanistic Insights.
ChainA
Resolution2.309 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.225: F-actin monooxygenase.
1.6.3.1: NAD(P)H oxidase (H2O2-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A V90 G91 G93 P94 C95 E114 R121 N123 L125 I157 K180 F181 A218 G219 Y293 G392 D393 W400 V83 G84 G86 P87 C88 E107 R114 N116 L118 I150 K173 F174 A211 G212 Y286 G385 D386 W393
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4txi, PDBe:4txi, PDBj:4txi
PDBsum4txi
PubMed26935886
UniProtQ8VDP3|MICA1_MOUSE [F-actin]-monooxygenase MICAL1 (Gene Name=Mical1)

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