Structure of PDB 4txe Chain A

Receptor sequence
>4txeA (length=288) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ANTNIAVYWGQNSAGTQESLATYCESSDADIFLLSFLNQFPTLGLNFANA
CSDTFSDGLLHCTQIAEDIETCQSLGKKVLLSLGGASGSYLFSDDSQAET
FAQTLWDTFGEGTGASERPFDSAVVDGFDFDIENNNEVGYSALATKLRTL
FAEGTKQYYLSAAPQCPYPDASVGDLLENADIDFAFIQFYNNYCSVSGQF
NWDTWLTYAQTVSPNKNIKLFLGLPGSASAAGSGYISDTSLLESTIADIA
SSSSFGGIALWDASQAFSNELNGEPYVEILKNLLTSAS
3D structure
PDB4txe Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.14: chitinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38F A Y32 Q35 F60 A110 D155 E157 A187 F210 Q212 Y214 W285 Y8 Q11 F36 A86 D131 E133 A163 F186 Q188 Y190 W261 MOAD: ic50=2.4uM
PDBbind-CN: -logKd/Ki=5.62,IC50=2.4uM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4txe, PDBe:4txe, PDBj:4txe
PDBsum4txe
PubMed25063338
UniProtP29029|CHIT_YEAST Endochitinase (Gene Name=CTS1)

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