Structure of PDB 4txc Chain A

Receptor sequence
>4txcA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
TVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKS
SRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGEL
FDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRN
VPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMW
SIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDF
IRRLLVKDPKKRMTIQDSLQHPWIKP
3D structure
PDB4txc Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.
ChainA
Resolution1.951 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V27 D139 K141 E143 N144 D161 T180
Catalytic site (residue number reindexed from 1) V26 D138 K140 E142 N143 D160 T179
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38G A L19 A40 K42 E64 I77 L93 V96 E143 N144 M146 D161 L18 A39 K41 E63 I76 L92 V95 E142 N143 M145 D160 MOAD: Kd=0.24uM
PDBbind-CN: -logKd/Ki=6.62,Kd=0.24uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:4txc, PDBe:4txc, PDBj:4txc
PDBsum4txc
PubMed25382253
UniProtP53355|DAPK1_HUMAN Death-associated protein kinase 1 (Gene Name=DAPK1)

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