Structure of PDB 4tx6 Chain A

Receptor sequence
>4tx6A (length=309) Species: 451804 (Aspergillus fumigatus A1163) [Search protein sequence]
SNLAIYWGQGPNQLRLSHFCQETSLDIINIGFINYFPDMSPGHWPGSNFG
NQCDGSVYVTNDGVVTKLLSGCHQIMEDIPICQAAGKKVLLSIGGAYPPD
QSILSEDSAVAFATFLWGAFGPVAEGWEGPRPFGDVVVDGFDFDIEHNGG
FGYATMVNTFRQYFNQVPERKFYLSAAPQCIIPDAQLSDAIFNAAFDFIW
IQYYNTAACSAKSFIDTSLGTFNFDAWVTVLKASASKDAKLYVGLPASET
AANQGYYLTPDEVESLVSTYMDRYPDTFGGIMLWEATASENNQIDGAPYA
DHMKDILLH
3D structure
PDB4tx6 Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.1.14: chitinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38B A Y34 G123 A124 D172 E174 Q230 Y232 W312 Y6 G95 A96 D144 E146 Q202 Y204 W284 MOAD: ic50=2.6uM
PDBbind-CN: -logKd/Ki=5.59,IC50=2.6uM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4tx6, PDBe:4tx6, PDBj:4tx6
PDBsum4tx6
PubMed25063338
UniProtB0Y2Y2

[Back to BioLiP]