Structure of PDB 4twj Chain A

Receptor sequence
>4twjA (length=236) Species: 224325 (Archaeoglobus fulgidus DSM 4304) [Search protein sequence]
MEDEIRKAAEILAKSKHAVVFTGAGISAEPEEVASISGFKRNPRAFWEFS
MEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLEL
HGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGE
PLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVN
AEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSEK
3D structure
PDB4twj Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N101 D103 H118
Catalytic site (residue number reindexed from 1) N84 D86 H101
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S67 H118 V163 F165 G166 E167 V195 V196 Y197 P198 S50 H101 V146 F148 G149 E150 V178 V179 Y180 P181
BS02 ZN A C126 C129 C150 C153 C109 C112 C133 C136
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0017136 NAD-dependent histone deacetylase activity
GO:0034979 NAD-dependent protein lysine deacetylase activity
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Biological Process
GO:0006338 chromatin remodeling
GO:0006476 protein deacetylation
GO:0036049 peptidyl-lysine desuccinylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4twj, PDBe:4twj, PDBj:4twj
PDBsum4twj
PubMed25200501
UniProtO30124|NPD2_ARCFU NAD-dependent protein deacylase 2 (Gene Name=cobB2)

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