Structure of PDB 4twe Chain A

Receptor sequence

>4tweA (length=706) Species: 9606 (Homo sapiens)

LAPQDLDLEILETVMGQLDAHRIRENLRELSREPHLASSPRDEDLVQLLL
QRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIVGPTGGIIHSCHRTE
ENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQGIKL
EGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFP
NSWYLPPSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQ
PIGFQDARDLLCNLNGTLAPATWQGALGCHYRLGPGFRPDGDFPADSQVN
VSVYNRLELRNSSNVLGIIRGAVEPDRYVLYGNHRDSWVHGAVDPSSGTA
VLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKL
QERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGDLSIY
DNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRS
KTSARIYPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFF
LPLKVSDYSETLRSFLQAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAA
LGQRISTLQKGSPDPLQVRMLNDQLMLLERTFLNPRAFPEERYYSHVLWA
PRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQLSIVVTALEGAAATL
RPVADL

3D structure

• PDB: 4twe Structural and biochemical characterization of a novel aminopeptidase from human intestine.
• Chain: A
• Resolution: 1.75 Å

Enzymatic activity

• Enzyme Commision number: 3.4.11.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	D378 E417 H545	D344 E383 H511
BS02	ZN	A	H368 D378 D445	H334 D344 D411
BS03	CA	A	T258 L261 E425 E428	T224 L227 E391 E394

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0004180 carboxypeptidase activity
• GO:0005509 calcium ion binding
• GO:0008233 peptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0042803 protein homodimerization activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0043171 peptide catabolic process

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0016324 apical plasma membrane

External links

• PDB: RCSB:4twe, PDBe:4twe, PDBj:4twe
• PDBsum: 4twe
• PubMed: 25752612
• UniProt: Q9UQQ1|NALDL_HUMAN Aminopeptidase NAALADL1 (Gene Name=NAALADL1)