Structure of PDB 4tw8 Chain A

Receptor sequence
>4tw8A (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
EGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSS
LDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPP
KIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIV
EVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVY
LKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKA
3D structure
PDB4tw8 Selective inhibitors of the FK506-binding protein 51 by induced fit.
ChainA
Resolution3.003 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y57 F67 D68 I87 Y113 F130
Catalytic site (residue number reindexed from 1) Y37 F47 D48 I67 Y93 F110
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 37M A Y57 G59 D68 E85 V86 I87 W90 Y113 K121 I122 F130 Y37 G39 D48 E65 V66 I67 W70 Y93 K101 I102 F110 PDBbind-CN: -logKd/Ki=5.58,Ki=2.611uM
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:4tw8, PDBe:4tw8, PDBj:4tw8
PDBsum4tw8
PubMed25436518
UniProtQ02790|FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4 (Gene Name=FKBP4)

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