Structure of PDB 4tvx Chain A

Receptor sequence
>4tvxA (length=192) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MYLSKVIIARAWSRDLYQLHQGLWHLFPDFLFHVEKRNTPEGCHVLLQSA
QMPVSTAVATVIKTKQVEFQLQVGVPLYFRLRANPIKTILDNQKRLDSKG
NIKRCRVPLIKEAEQIAWLQRKLGNAARVEDVHPISERPQYFSGDGKSGK
IQTVCFEGVLTINDAPALIDLVQQGIGPAKSMGCGLLSLAPL
3D structure
PDB4tvx Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli.
ChainA
Resolution3.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 rna A Y17 N91 K94 T95 I96 D98 N99 Q100 R102 K110 R111 C112 R113 V114 P115 R128 K129 F149 S155 G156 K157 Q159 K187 S188 Y17 N84 K87 T88 I89 D91 N92 Q93 R95 K103 R104 C105 R106 V107 P108 R121 K122 F142 S148 G149 K150 Q152 K180 S181
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
Biological Process
GO:0006396 RNA processing
GO:0051607 defense response to virus
GO:0099048 CRISPR-cas system
Cellular Component
GO:0032991 protein-containing complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:4tvx, PDBe:4tvx, PDBj:4tvx
PDBsum4tvx
PubMed25103409
UniProtQ46897|CAS6_ECOLI CRISPR system Cascade subunit CasE (Gene Name=casE)

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