Structure of PDB 4tvm Chain A

Receptor sequence
>4tvmA (length=380) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTFDVGFANTAAAK
SSITYIDGDAGILRYRGYPIDQLAEKSTFIEVCYLLIYGELPDTDQLAQF
TGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSAYYQDALDPMD
NGQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNSLTLVENFLRLTFG
FPAEPYQADPEVVRALDMLFILHADHEQNCSTSTVRLVGSSRANLFTSIS
GGINALWGPLHGGANQAVLEMLEGIRDSGDDVSENYDPRARIVKEQADKI
LGDDSLLGIAKELEEAVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAH
WREMHDEGDSKIGRPRQIYTGYTERDYVTI
3D structure
PDB4tvm Structures of citrate synthase and malate dehydrogenase of Mycobacterium tuberculosis.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S237 H267 R318 D366
Catalytic site (residue number reindexed from 1) S231 H261 R289 D318
Enzyme Commision number 2.3.3.16: citrate synthase (unknown stereospecificity).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OAA A H232 N235 F387 R391 H226 N229 F339 R343
Gene Ontology
Molecular Function
GO:0004108 citrate (Si)-synthase activity
GO:0016740 transferase activity
GO:0036440 citrate synthase activity
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
Biological Process
GO:0006099 tricarboxylic acid cycle
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4tvm, PDBe:4tvm, PDBj:4tvm
PDBsum4tvm
PubMed25524525
UniProtP9WPD5|CISY1_MYCTU Citrate synthase 1 (Gene Name=gltA2)

[Back to BioLiP]