Structure of PDB 4tuh Chain A

Receptor sequence
>4tuhA (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]
PLGSMSQSNRELVVDFLSYKLSQKGYSWSQMAAVKQALREAGDEFELRYR
RAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCV
ESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
3D structure
PDB4tuh Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38H A A93 E96 F97 Y101 R102 F105 S106 L108 T109 L130 N136 G138 R139 A142 S145 F146 A149 Y195 A41 E44 F45 Y49 R50 F53 S54 L56 T57 L78 N84 G86 R87 A90 S93 F94 A97 Y143 PDBbind-CN: -logKd/Ki=4.00,IC50>100uM
BindingDB: Ki=0.380000nM,EC50=60nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4tuh, PDBe:4tuh, PDBj:4tuh
PDBsum4tuh
PubMed24944740
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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