Structure of PDB 4tu0 Chain A

Receptor sequence
>4tu0A (length=162) Species: 37124 (Chikungunya virus) [Search protein sequence]
HHAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNS
ATPVGTAKTVMCGTYPVIHAVGPNFSNYSESEGDRELAAAYREVAKEVTR
LGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEW
EKKISEAIQMRT
3D structure
PDB4tu0 CRYSTAL STRUCTURE OF CHIKUNGUNYA VIRUS NSP3 MACRO DOMAIN IN COMPLEX WITH A 2'-5' OLIGOADENYLATE TRIMER
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A D12 I13 G34 V35 T113 G114 V115 R146 D147 W150 D12 I13 G34 V35 T113 G114 V115 R146 D147 W150
External links
PDB RCSB:4tu0, PDBe:4tu0, PDBj:4tu0
PDBsum4tu0
PubMed
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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