Structure of PDB 4tsx Chain A

Receptor sequence
>4tsxA (length=145) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
DCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKL
AGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPESMNKELKKIIG
QVRDQAETLKTAVQMAVFIHNKKRKGGGGYSAGERIVDIIATDIQ
3D structure
PDB4tsx The mechanism of H171T resistance reveals the importance of N -protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.
ChainA
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LF0 A Q95 L102 T124 T125 A128 A129 W132 Q41 L48 T70 T71 A74 A75 W78 MOAD: Kd=10.3uM
PDBbind-CN: -logKd/Ki=4.99,Kd=10.3uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:4tsx, PDBe:4tsx, PDBj:4tsx
PDBsum4tsx
PubMed25421939
UniProtF2WR39

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