Structure of PDB 4tsm Chain A

Receptor sequence

>4tsmA (length=505) Species: 562 (Escherichia coli) [Search protein sequence]

MKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQ
VAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRY
NGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMF
NLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLI
KNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPT
FKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPL
GAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVIN
AASGRQTVDAALAAAQTNAAASNINKAKVASVESDYSSVKSAALSYYSDT
NKIPVTPDGQTGLSVLETYMESLPDKADIGGKYKLIKVGNKLVLQIGTND
EGVTLTEAQSAKLLSDIGENKIYTSVTADNLGNPLTSNTKVDNKVLYIVL
IDNTV

3D structure

PDB

4tsm Structural and Evolutionary Analyses Show Unique Stabilization Strategies in the Type IV Pili of Clostridium difficile.

Chain

Resolution

1.899 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	A	D14 K15 E111 Y155 W230	D15 K16 E112 Y156 W231
BS02	GLC	A	W62 D65 E153 P154 Y155 W340	W63 D66 E154 P155 Y156 W341
BS03	GLC	A	E44 R66 E153 W340 Y341 R344	E45 R67 E154 W341 Y342 R345
BS04	GLC	A	E44 E45 R344	E45 E46 R345
BS05	TMO	A	P271 N272 K273 E274	P272 N273 K274 E275
BS06	TMO	A	P40 D41	P41 D42
BS07	TMO	A	G13 H39	G14 H40
BS08	TMO	A	A77 K273	A78 K274
BS09	TMO	A	A82 A83	A83 A84
BS10	TMO	A	N185 A186	N186 A187
BS11	TMO	A	M0 K1	M1 K2

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0015144	carbohydrate transmembrane transporter activity
GO:1901982	maltose binding

	Biological Process
GO:0006974	DNA damage response
GO:0008643	carbohydrate transport
GO:0015768	maltose transport
GO:0034219	carbohydrate transmembrane transport
GO:0034289	detection of maltose stimulus
GO:0042956	maltodextrin transmembrane transport
GO:0055085	transmembrane transport
GO:0060326	cell chemotaxis

	Cellular Component
GO:0016020	membrane
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space
GO:0043190	ATP-binding cassette (ABC) transporter complex
GO:0055052	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060	maltose transport complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4tsm, PDBe:4tsm, PDBj:4tsm
PDBsum	4tsm
PubMed	25599642
UniProt	P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE)

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