Structure of PDB 4ts1 Chain A

Receptor sequence
>4ts1A (length=317) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence]
MDLLAELQWRGLVNQTTDEDGLRKLLNEERVTLYCGFDPTADSLHIGHLA
TILTMRRFQQAGHRPIALVGGATGLIGDPSGKKSERTLNAKETVEAWSAR
IKEQLGRFLDFEADGNPAKIKNNYDWIGPLDVITFLRDVGKHFSVNYMMA
KESVQSRIETGISFTEFSYMMLQAYDFLRLYETEGCRLQIGGSDQWGNIT
AGLELIRKTKGRAFGLTIPLVTKADGTKFGKTESGTIWLDKEKTSPYEFY
QFWINTDDRDVIRYLKYFTFLSKEEIEALEQELREAPEKRAAQKTLAEEV
TKLVHGEEALRQAIRYA
3D structure
PDB4ts1 Crystal structure of a deletion mutant of a tyrosyl-tRNA synthetase complexed with tyrosine.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T40 H45 H48 K82 R86 Q173 D194 K230 K233 T234
Catalytic site (residue number reindexed from 1) T40 H45 H48 K82 R86 Q173 D194 K228 K231 T232
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYR A Y34 G36 D78 Y169 Q173 D176 Q195 Y34 G36 D78 Y169 Q173 D176 Q195 MOAD: Kd=11.6uM
PDBbind-CN: -logKd/Ki=4.94,Kd=11.6uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ts1, PDBe:4ts1, PDBj:4ts1
PDBsum4ts1
PubMed3612807
UniProtP00952|SYY_GEOSE Tyrosine--tRNA ligase (Gene Name=tyrS)

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