Structure of PDB 4tqs Chain A

Receptor sequence
>4tqsA (length=342) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence]
MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEA
RKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIE
IASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVF
AKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGIN
KLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVT
MKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGR
TFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFIE
3D structure
PDB4tqs Kinetic and Structural Mechanisms of (5'S)-8,5'-Cyclo-2'-deoxyguanosine-Induced DNA Replication Stalling.
ChainA
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A G185 G187 I189 T190 R298 T301 G185 G187 I189 T190 R298 T301
BS02 dna A S34 G41 G58 P60 K221 K243 I248 T250 S34 G41 G58 P60 K221 K243 I248 T250
BS03 DCP A Y10 T45 R51 A57 D105 Y10 T45 R51 A57 D105
BS04 MG A D7 F8 D105 D7 F8 D105
BS05 MG A D7 D105 E106 D7 D105 E106
BS06 DOC A E106 K152 E106 K152
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0042276 error-prone translesion synthesis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4tqs, PDBe:4tqs, PDBj:4tqs
PDBsum4tqs
PubMed25569151
UniProtQ97W02|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)

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