Structure of PDB 4tpw Chain A

Receptor sequence
>4tpwA (length=185) Species: 9606 (Homo sapiens) [Search protein sequence]
HYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLS
SNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLE
TLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRV
YKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
3D structure
PDB4tpw Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MGP A W56 M101 W102 E103 R157 K162 W24 M69 W70 E71 R125 K130 BindingDB: Ki=28nM
BS02 33R A F47 K49 N59 R61 I63 H78 F15 K17 N27 R29 I31 H46 MOAD: Kd=20.5uM
PDBbind-CN: -logKd/Ki=4.69,Kd=20.5uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4tpw, PDBe:4tpw, PDBj:4tpw
PDBsum4tpw
PubMed25049413
UniProtP06730|IF4E_HUMAN Eukaryotic translation initiation factor 4E (Gene Name=EIF4E)

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