Structure of PDB 4tos Chain A

Receptor sequence
>4tosA (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
SGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKV
VNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAY
IGGMAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVT
LGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYL
ITYQIMKP
3D structure
PDB4tos Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.
ChainA
Resolution1.802 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1234 H1237 C1242 C1245 C129 H132 C137 C140
BS02 355 A H1184 G1185 S1186 P1187 F1188 K1195 G1196 F1197 D1198 H1201 A1202 G1205 M1207 Y1213 K1220 Y1224 G1227 I1228 H81 G82 S83 P84 F85 K92 G93 F94 D95 H98 A99 G102 M104 Y108 K115 Y119 G122 I123
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tos, PDBe:4tos, PDBj:4tos
PDBsum4tos
PubMed25939383
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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