Structure of PDB 4to1 Chain A

Receptor sequence

>4to1A (length=479) Species: 9606 (Homo sapiens) [Search protein sequence]

TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDC
HHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLH
RRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYT
KLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKR
EDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSF
YCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFV
QWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4to1 Structural basis of cellular dNTP regulation by SAMHD1.

Chain

Resolution

2.55 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DCP	A	L150 R164 R206 H210 H215 H233 Y315 D319 R366 Y374	L37 R51 R93 H97 H102 H120 Y195 D199 R246 Y254
BS02	DTP	A	R333 R352 K354 N358 K523	R213 R232 K234 N238 K403
BS03	DTP	A	V117 N119	V4 N6
BS04	DCP	A	V156 F157 R372 H376 K377	V43 F44 R252 H256 K257
BS05	GTP	A	Y155 V156 V378 R451	Y42 V43 V258 R331
BS06	GTP	A	K116 V117 I118 D137 R145	K3 V4 I5 D24 R32

External links

PDB	RCSB:4to1, PDBe:4to1, PDBj:4to1
PDBsum	4to1
PubMed	25267621
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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