Structure of PDB 4tnd Chain A

Receptor sequence
>4tndA (length=529) Species: 9606 (Homo sapiens) [Search protein sequence]
AREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGR
LLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKKIMTKYLTPKS
PVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDS
MFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYAC
KRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLT
IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVYRDLKP
ENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL
SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSE
EAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPP
FVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNE
MIETECFKELNVFGPNGTLPPDLNRNHPP
3D structure
PDB4tnd Atomic Structure of G Protein-Coupled Receptor Kinase 5 (GRK5) Reveals Distinct Structural Features Novel for GRKs.
ChainA
Resolution1.802 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D311 K313 E315 N316 D329 E338 T348
Catalytic site (residue number reindexed from 1) D297 K299 E301 N302 D315 E324 T334
Enzyme Commision number 2.7.11.16: [G-protein-coupled receptor] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A G193 G195 A213 M266 L318 D329 R470 G179 G181 A199 M252 L304 D315 R456
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G protein-coupled receptor kinase activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0047696 beta-adrenergic receptor kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007217 tachykinin receptor signaling pathway
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0009966 regulation of signal transduction
GO:0016055 Wnt signaling pathway
GO:0016310 phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0045444 fat cell differentiation
GO:0046777 protein autophosphorylation
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016607 nuclear speck
GO:0031965 nuclear membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4tnd, PDBe:4tnd, PDBj:4tnd
PDBsum4tnd
PubMed26032409
UniProtP34947|GRK5_HUMAN G protein-coupled receptor kinase 5 (Gene Name=GRK5)

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