Structure of PDB 4tn7 Chain A

Receptor sequence
>4tn7A (length=329) Species: 10090 (Mus musculus) [Search protein sequence]
RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME
3D structure
PDB4tn7 A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M111 Q116 I144 S145 N186 A187 I188 Y199 N298 K323 F324 R325 M76 Q81 I109 S110 N151 A152 I153 Y164 N263 K288 F289 R290
BS02 FE A H212 D214 H284 H177 D179 H249
External links
PDB RCSB:4tn7, PDBe:4tn7, PDBj:4tn7
PDBsum4tn7
PubMed25128496
UniProtP59997|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)

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