Structure of PDB 4tn2 Chain A

Receptor sequence
>4tn2A (length=561) Species: 10407 (Hepatitis B virus) [Search protein sequence]
ASYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKK
VTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKF
GYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQRKP
ARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVN
TWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKSL
TERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAA
KLQDCTMLVNGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQP
EYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVN
SWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEP
LDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARS
VRARLLSQGGRAATCGKYLFNWAVKTKLKLFQGPAASQLDLSGWFVAGYS
GGDIYHSLSRA
3D structure
PDB4tn2 Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 33J A L419 R422 M423 H475 S476 Y477 I482 L497 W528 L413 R416 M417 H469 S470 Y471 I476 L491 W522 PDBbind-CN: -logKd/Ki=6.92,IC50=0.12uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4tn2, PDBe:4tn2, PDBj:4tn2
PDBsum4tn2
PubMed24986660
UniProtP26663|POLG_HCVBK Genome polyprotein

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