Structure of PDB 4tmw Chain A

Receptor sequence
>4tmwA (length=343) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence]
HMNKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATY
FPVEAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCNI
AILVVDIMHGLEPQTIESLRLLRERKTPFVVALNKIDRLYGWKKIENNGF
RESFALQNKAVQNEFRNRLDQVKLQFAEQGFNSELFYENKNFARYVSLVP
TSAHTGEGIPDMLKLIVQLCQERMASSLMYLSELQATVLEVKAIEGFGVT
IDVILSNGILREGDRIVLCGLEGPIKTNIRALLTPAPMRELRIKGQYIHH
KEVKAAQGVKISAPGLEGAIAGSRLLVVGPDDDEEELEEEVES
3D structure
PDB4tmw A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A V532 D533 T534 G535 K536 T537 K538 Q549 I556 T557 G597 N648 K649 D651 S716 A717 H718 V18 D19 T20 G21 K22 T23 K24 Q35 I42 T43 G83 N134 K135 D137 S202 A203 H204 MOAD: Kd=4.1uM
BS02 MG A T537 T557 T23 T43
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4tmw, PDBe:4tmw, PDBj:4tmw
PDBsum4tmw
PubMed25225612
UniProtG0S8G9|IF2P_CHATD Eukaryotic translation initiation factor 5B (Gene Name=CTHT_0029840)

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