Structure of PDB 4tlm Chain A

Receptor sequence
>4tlmA (length=796) Species: 8355 (Xenopus laevis) [Search protein sequence]
DPKIVNIGAVLSTKKHEQIFREAVNQANFFHFTRKIQLNATSVTHRPNAI
QMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLT
TRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHE
GRAAQKKLETLLEEKESKADKVLQFEPGTKNLTALLLEAKELEARVIILS
ASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLI
NGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNTNIWKTGPLFK
RVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFDGSYI
IQNDRKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVRPTTSDGTCRE
EYTINGDPIKKVICNGPDETIPGRPTVPQCCYGFCVDLLIKLAREMDFTY
EVHLVADGKFGTQERVNNSNAAAWNGMMGELLSGQADMIVAPLTINNERA
QYIEFSKPFKYQGLTILVKKEIPRDSFMQPFQSTLWLLVGLSVHVVAVML
YLLDRFSLTLSSAMWFSWRVLLNSGLGEGAPRSFSARILGMVWAGFAMII
VASYTANLAAFLVLRRITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQV
ELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLV
TTGELFFRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEELDKTWVRYQE
CDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKSRAEA
3D structure
PDB4tlm NMDA receptor structures reveal subunit arrangement and pore architecture.
ChainA
Resolution3.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1AC A F482 L515 T516 R521 S678 D722 F460 L493 T494 R499 S641 D685
BS02 QEM A Y109 S132 I133 L135 Y87 S110 I111 L113
Gene Ontology
Molecular Function
GO:0004972 NMDA glutamate receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005515 protein binding
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0015280 ligand-gated sodium channel activity
GO:0022849 glutamate-gated calcium ion channel activity
GO:0038023 signaling receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0007268 chemical synaptic transmission
GO:0010043 response to zinc ion
GO:0019722 calcium-mediated signaling
GO:0034220 monoatomic ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0017146 NMDA selective glutamate receptor complex
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0098839 postsynaptic density membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4tlm, PDBe:4tlm, PDBj:4tlm
PDBsum4tlm
PubMed25008524
UniProtA0A1L8F5J9|NMDZ1_XENLA Glutamate receptor ionotropic, NMDA 1 (Gene Name=grin1)

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