Structure of PDB 4tki Chain A

Receptor sequence
>4tkiA (length=199) Species: 9606 (Homo sapiens) [Search protein sequence]
DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTH
RRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYF
AENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS
AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP
3D structure
PDB4tki Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1081 H1084 C1089 C1092 C120 H123 C128 C131
BS02 33E A H1031 G1032 Y1050 Y1060 S1068 Y1071 H70 G71 Y89 Y99 S107 Y110 PDBbind-CN: -logKd/Ki=6.38,IC50=0.416uM
BS03 33E A F1035 A1038 I1039 H1048 F74 A77 I78 H87 PDBbind-CN: -logKd/Ki=6.38,IC50=0.416uM
BS04 33E A K999 C1001 N1002 K1003 W1006 Y1148 E1150 K38 C40 N41 K42 W45 Y187 E189 PDBbind-CN: -logKd/Ki=6.38,IC50=0.416uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tki, PDBe:4tki, PDBj:4tki
PDBsum4tki
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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