Structure of PDB 4tkg Chain A

Receptor sequence
>4tkgA (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTH
RRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYF
AENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS
AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
3D structure
PDB4tkg Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1081 H1084 C1089 C1092 C120 H123 C128 C131
BS02 09L A H1031 G1032 I1039 H1048 Y1050 I1059 Y1060 F1061 S1068 Y1071 I1075 E1138 H70 G71 I78 H87 Y89 I98 Y99 F100 S107 Y110 I114 E177 PDBbind-CN: -logKd/Ki=6.85,IC50=0.140uM
BindingDB: IC50=2340nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tkg, PDBe:4tkg, PDBj:4tkg
PDBsum4tkg
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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