Structure of PDB 4tjw Chain A

Receptor sequence
>4tjwA (length=199) Species: 9606 (Homo sapiens) [Search protein sequence]
KEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHR
RKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFA
ENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSA
MKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
3D structure
PDB4tjw Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1081 H1084 C1089 C1092 C119 H122 C127 C130
BS02 P34 A H1031 G1032 Y1050 G1053 G1056 Y1060 F1061 K1067 S1068 Y1071 I1075 E1138 H69 G70 Y88 G91 G94 Y98 F99 K105 S106 Y109 I113 E176 PDBbind-CN: -logKd/Ki=6.02,IC50=0.963uM
BindingDB: IC50=2951nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tjw, PDBe:4tjw, PDBj:4tjw
PDBsum4tjw
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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