Structure of PDB 4sli Chain A

Receptor sequence
>4sliA (length=679) Species: 6405 (Macrobdella decora) [Search protein sequence]
IPEGILMEKNNVDIAEGQGYSLDQEAGAKYVKAMTQGTIILSYKSTSENG
IQSLFSVGNSTAGNQDRHFHIYITNSGGIGIELRNTDGVFNYTLDRPASV
RALYKGERVFNTVALKADAANKQCRLFANGELLATLDKDAFKFISDITGV
DNVTLGGTKRQGKIAYPFGGTIGDIKVYSNALSDEELIQATGVTTYGENI
FYAGDVTESNYFRIPSLLTLSTGTVISAADARYGGTHDSKSKINIAFAKS
TDGGNTWSEPTLPLKFDDYIAKNIDWPRDSVGKNVQIQGSASYIDPVLLE
DKLTKRIFLFADLMPAGIGSSNASVGSGFKEVNGKKYLKLRWHKDAGRAY
DYTIREKGVIYNDATNQPTEFRVDGEYNLYQHDTNLTCKQYDYNFSGNNL
IESKTDVDVNMNIFYKNSVFKAFPTNYLAMRYSDDEGASWSDLDIVSSFK
PEVSKFLVVGPGIGKQISTGENAGRLLVPLYSKSSAELGFMYSDDHGDNW
TYVEADNLTGGATAEAQIVEMPDGSLKTYLRTGSNCIAEVTSIDGGETWS
DRVPLQGISTTSYGTQLSVINYSQPIDGKPAIILSSPNATNGRKNGKIWI
GLVNDTGNTGIDKYSVEWKYSYAVDTPQMGYSYSCLAELPDGQVGLLYEK
YDSWSRNELHLKDILKFEKYSISELTGQA
3D structure
PDB4sli The 1.8 A structures of leech intramolecular trans-sialidase complexes: evidence of its enzymatic mechanism.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H317 D318 E595 Y713
Catalytic site (residue number reindexed from 1) H237 D238 E515 Y633
Enzyme Commision number 4.2.2.15: anhydrosialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CNP A R293 D318 D375 T593 R611 R673 Y713 R213 D238 D295 T513 R531 R593 Y633
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016829 lyase activity
GO:0033995 anhydrosialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4sli, PDBe:4sli, PDBj:4sli
PDBsum4sli
PubMed9878409
UniProtQ27701|NANL_MACDE Anhydrosialidase

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