Structure of PDB 4s1h Chain A

Receptor sequence
>4s1hA (length=287) Species: 5759 (Entamoeba histolytica) [Search protein sequence]
MTNKVLTISSYVCSGFVGNRCGMIILDSFQIQSIFVLTTHLANHTGYPVV
GGSGVLLNDFISIMDSLEVNHLDKDIEFLVTGYFPSSDLVYETINRVKRI
KDNKKVYFLCDPILGDNGKMYTKSEVQDSMKELIKYADIITPNATELSFL
TGLEVNSVSEAIKACHILHEQGIPVILVTSIKEGNDIILLCSFKDTLNNK
NFTIKIPRIEGDFTGVGDTLTYILLSWIIKGIPLEHAVNRAISTLQTILR
NTVGTAEINIINCIPYLKGTEESFTITYILEHHHHHH
3D structure
PDB4s1h Characterization and functional insights into the Entamoeba histolytica pyridoxal kinase, an enzyme essential for its survival.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G215 V216 G217 D218
Catalytic site (residue number reindexed from 1) G215 V216 G217 D218
Enzyme Commision number 2.7.1.35: pyridoxal kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A D116 T179 S180 I187 R208 I209 V216 G217 I242 L245 Q246 L249 D116 T179 S180 I187 R208 I209 V216 G217 I242 L245 Q246 L249
BS02 MG A D111 T141 D111 T141
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008478 pyridoxal kinase activity
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009443 pyridoxal 5'-phosphate salvage
GO:0016310 phosphorylation
GO:0042816 vitamin B6 metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4s1h, PDBe:4s1h, PDBj:4s1h
PDBsum4s1h
PubMed33045383
UniProtC4LVZ4

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