Structure of PDB 4s0n Chain A

Receptor sequence
>4s0nA (length=122) Species: 9606 (Homo sapiens) [Search protein sequence]
DSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNG
NQVGHLKKELAGALAYIMDNKLAQIEGVVPFGANNAFTMPLHMTFWGKEE
NRKAVSDQLKKHGFKLGPAPKT
3D structure
PDB4s0n HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.
ChainA
Resolution1.501 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A G69 Y72 Y73 Y93 D94 H110 K112 K113 F142 G14 Y17 Y18 Y38 D39 H55 K57 K58 F87 PDBbind-CN: Kd=13nM
BS02 DT A Q86 D88 P89 N90 K99 Q31 D33 P34 N35 K44
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

View graph for
Molecular Function
External links
PDB RCSB:4s0n, PDBe:4s0n, PDBj:4s0n
PDBsum4s0n
PubMed26051180
UniProtQ14527|HLTF_HUMAN Helicase-like transcription factor (Gene Name=HLTF)

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