Structure of PDB 4rzv Chain A

Receptor sequence
>4rzvA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAF
KNEVGVLRKTHHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKF
EMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLA
TVLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRI
LAEIEELAREL
3D structure
PDB4rzv An integrated model of RAF inhibitor action predicts inhibitor activity against oncogenic BRAF signaling
ChainA
Resolution2.994 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D128 K130 N132 N133 D146 S156
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 032 A I463 V471 A481 K483 L514 T529 W531 C532 S535 H539 F583 D594 F595 G596 I15 V23 A33 K35 L66 T81 W83 C84 S87 H91 F135 D146 F147 G148 BindingDB: IC50=31nM,Kd=51nM,EC50=2290nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4rzv, PDBe:4rzv, PDBj:4rzv
PDBsum4rzv
PubMed
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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