Structure of PDB 4rz7 Chain A

Receptor sequence
>4rz7A (length=801) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
GMRCNERNKKKAIFGEDTLMEDHLQLREKLSEDIEMIKASLKNNLVCSTL
NDNEILTLSNYMQFFVFKGGDLVIKQGEKGSYFFIINSGKFDVYVNKVKS
MGKGSSFGEAALIHNTQRSATIMAETDTLWGVQRSTFRATLKQLSNRNFN
ENRSFIDSVSVFDMLTEAQKNMITNACVIQMFKPGETIVKQGDYGDVLFI
LKEGKATVFINDKEIRVLNKGSYFGERALLYDEPRSATIIAKEPTACASI
CRKLLNIVLGNLQVVLFRNIMTEALQQSEIFRQFSAEQLNDLADTAIVRD
YPANYHILHKDKVKSVKYLIVLEGKVELFLDDESIGILTRGKSFGDQYVL
NQKQKFRHTVKSLDVCKIALITESCLADCLGDNNIDASIDHNNKKSIIKK
MYIFRYLSEQQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEV
TKNGKRLRTLGKNDYFGERALLYDEPRTASIISKATSVECWFVDKSVFLQ
IIQGPMLTHLEERIKMQDTKVEMHELETERIIGRGGTVKLVHHKPTQIRY
ALKCVSKRSIIQNNIKLEREITAENDHPFIIRLVRTFKDSNCFYFLTELV
TGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYRDLKPENIL
LDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILGKGYGCTVDIWA
LGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLMK
RLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGET
Y
3D structure
PDB4rz7 Crystal Structure of PVX_084705 with bound PCI32765
ChainA
Resolution2.351 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D657 K659 N662 D675 T692
Catalytic site (residue number reindexed from 1) D643 K645 N648 D661 T678
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1E8 A A561 T586 F609 T611 L613 V614 A551 T572 F595 T597 L599 V600
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding
GO:0030553 cGMP binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4rz7, PDBe:4rz7, PDBj:4rz7
PDBsum4rz7
PubMed
UniProtA5K0N4|KGP_PLAVS cGMP-dependent protein kinase (Gene Name=PKG)

[Back to BioLiP]