Structure of PDB 4rxr Chain A

Receptor sequence
>4rxrA (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DIYFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN
3D structure
PDB4rxr The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
ChainA
Resolution2.117 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DCP A L150 R164 H215 K312 Y315 D319 H370 Y374 L37 R51 H102 K194 Y197 D201 H252 Y256
BS02 DCP A V156 F157 R372 H376 K377 V43 F44 R254 H258 K259
BS03 GTP A K116 V117 I118 D137 R145 K3 V4 I5 D24 R32
BS04 DCP A V117 N119 V4 N6
BS05 GTP A Y155 V156 V378 R451 Y42 V43 V260 R333
External links
PDB RCSB:4rxr, PDBe:4rxr, PDBj:4rxr
PDBsum4rxr
PubMed25760601
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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