Structure of PDB 4rx0 Chain A

Receptor sequence
>4rx0A (length=367) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
YNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACT
NIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAK
PRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGV
SIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPEAGKLKNIILSVKE
EIDNLEKNNIMNDEFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLET
NIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQ
IPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHL
LYQRGYYNLKEAIGRKH
3D structure
PDB4rx0 A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) G248 N274 F278 S345 K429 N458
Catalytic site (residue number reindexed from 1) G88 N114 F118 S185 K230 N259
Enzyme Commision number 1.3.5.2: dihydroorotate dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D65 A L172 L176 G181 C184 H185 F188 L197 F227 I263 R265 M536 L12 L16 G21 C24 H25 F28 L37 F67 I103 R105 M337 BindingDB: IC50=10.0nM
BS02 FMN A A225 G226 K229 T249 N274 K429 S477 G478 S505 G506 G507 Y528 S529 A65 G66 K69 T89 N114 K230 S278 G279 S306 G307 G308 Y329 S330
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4rx0, PDBe:4rx0, PDBj:4rx0
PDBsum4rx0
PubMed26180101
UniProtQ08210|PYRD_PLAF7 Dihydroorotate dehydrogenase (quinone), mitochondrial (Gene Name=PFF0160c)

[Back to BioLiP]