Structure of PDB 4rwp Chain A

Receptor sequence
>4rwpA (length=346) Species: 9823 (Sus scrofa) [Search protein sequence]
MELRHTPARDLDKFIEDHLLPNTCFRTQVKEAIDIVCRFLKERCFQGTAD
PVRVSKVVKGGSSGKGTTLRGRSDADLVVFLTKLTSFEDQLRRRGEFIQE
IRRQLEACQREQKFKVTFEVQSPRRENPRALSFVLSSPQLQQEVEFDVLP
AFDALGQWTPGYKPNPEIYVQLIKECKSRGKEGEFSTCFTELQRDFLRNR
PTKLKSLIRLVKHWYQTCKKTHGNKLPPQYALELLTVYAWEQGSRKTDFS
TAQGFQTVLELVLKHQKLCIFWEAYYDFTNPVVGRCMLQQLKKPRPVILD
PADPTGNVGGGDTHSWQRLAQEARVWLGYPCCKNLDGSLVGAWTML
3D structure
PDB4rwp The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.84: 2'-5' oligoadenylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A P21 T23 R38 K41 E42 R53 V54 S55 G66 R198 N199 K205 P21 T23 R38 K41 E42 R53 V54 S55 G66 R198 N199 K205
BS02 rna A D12 K13 E16 K30 D34 K56 V57 K59 Q157 R194 T202 K203 T247 D12 K13 E16 K30 D34 K56 V57 K59 Q157 R194 T202 K203 T247
Gene Ontology
Molecular Function
GO:0001730 2'-5'-oligoadenylate synthetase activity
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:0060700 regulation of ribonuclease activity
GO:1904188 negative regulation of transformation of host cell by virus
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4rwp, PDBe:4rwp, PDBj:4rwp
PDBsum4rwp
PubMed25892109
UniProtQ29599|OAS1_PIG 2'-5'-oligoadenylate synthase 1 (Gene Name=OAS1)

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