Structure of PDB 4rwk Chain A

Receptor sequence
>4rwkA (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
MAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPN
RVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGP
LYVIMEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQ
VARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKK
TTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV
EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
IVALTSNQ
3D structure
PDB4rwk Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance for the FGFR1 Gatekeeper Mutation: The Achilles' Heel of Targeted Therapy.
ChainA
Resolution2.982 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D623 A625 R627 N628 D641
Catalytic site (residue number reindexed from 1) D167 A169 R171 N172 D185
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 66T A L484 V492 A512 A564 S565 G567 L630 D641 L28 V36 A56 A108 S109 G111 L174 D185 PDBbind-CN: -logKd/Ki=7.19,Kd=64nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor receptor activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4rwk, PDBe:4rwk, PDBj:4rwk
PDBsum4rwk
PubMed25686244
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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