Structure of PDB 4rwg Chain A

Receptor sequence

>4rwgA (length=557) Species: 9606,83333 [Search protein sequence]

KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTNAAAEFTTACQEANYGALLRELCLTQFQVDMEAV
GETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYF
RSCPISGRAQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWL
CWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTN
YTQCNVN

3D structure

PDB

4rwg Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.

Chain

Resolution

2.44 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Y343 R356 A372 F374 W1084 D2070 G2071 W2072 D2094 H2114 A2116 S2117 R2119 W2121 T2122 N2128	Y341 R354 A370 F372 W433 D497 G498 W499 D521 H541 A543 S544 R546 W548 T549 N555
BS02	GLC	A	D16 K17 E113 Y157 W232	D14 K15 E111 Y155 W230
BS03	GLC	A	W64 D67 R68 E155 P156 Y157 W342	W62 D65 R66 E153 P154 Y155 W340

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0015026	coreceptor activity
GO:0015144	carbohydrate transmembrane transporter activity

	Biological Process
GO:0006886	intracellular protein transport
GO:0007186	G protein-coupled receptor signaling pathway
GO:0008277	regulation of G protein-coupled receptor signaling pathway
GO:0008643	carbohydrate transport
GO:0055085	transmembrane transport

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4rwg, PDBe:4rwg, PDBj:4rwg
PDBsum	4rwg
PubMed	25982113
UniProt	O60894\|RAMP1_HUMAN Receptor activity-modifying protein 1 (Gene Name=RAMP1); P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q16602\|CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (Gene Name=CALCRL)

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