Structure of PDB 4rwf Chain A

Receptor sequence

>4rwfA (length=555) Species: 9606,83333 [Search protein sequence]

KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTNAAAEFGGTVKNYETAVQFCWNHYKDQMDPIEKD
WCDWAMISRPYSTLRDCLEHFAERFDLGFPNPLAERIIFETHQIHFANCS
LVQPTFSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLC
WNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNY
TQCNV

3D structure

PDB

4rwf Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.

Chain

Resolution

1.76 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	R1097 E1101 F1111 T2037 D2070 W2072 D2090 F2092 Q2093 D2094 F2095 H2114 S2117 R2119 W2121 T2122	R415 E419 F429 T463 D496 W498 D516 F518 Q519 D520 F521 H540 S543 R545 W547 T548
BS02	GLC	A	D16 K17 E113 Y157 W232 W2121	D14 K15 E111 Y155 W230 W547
BS03	GLC	A	W64 D67 R68 E155 P156 Y157 W342	W62 D65 R66 E153 P154 Y155 W340

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0015026	coreceptor activity
GO:0015144	carbohydrate transmembrane transporter activity

	Biological Process
GO:0006886	intracellular protein transport
GO:0007186	G protein-coupled receptor signaling pathway
GO:0008277	regulation of G protein-coupled receptor signaling pathway
GO:0008643	carbohydrate transport
GO:0055085	transmembrane transport

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4rwf, PDBe:4rwf, PDBj:4rwf
PDBsum	4rwf
PubMed	25982113
UniProt	O60895\|RAMP2_HUMAN Receptor activity-modifying protein 2 (Gene Name=RAMP2); P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q16602\|CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (Gene Name=CALCRL)

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