Structure of PDB 4rw5 Chain A

Receptor sequence
>4rw5A (length=278) Species: 58218 (Loxosceles intermedia) [Search protein sequence]
GNRRPIWIMGAMVNAIGQIDEFVNLGANSIETDVSFDDNANPEYTYHGIP
CDCGRNCKKYENFNDFLKGLRSATTPGNSKYQEKLVLVVFDLKTGSLYDN
QANDAGKKLAKNLLQHYWNNGNNGGRAYIVLSIPDLNHYPLIKGFKDQLT
KDGHPELMDKVGHDFSGNDDIGDVGKAYKKAGITGHIWQSDGITNCLPRG
LSRVNAAVANRDSANGFINKVYYWTVDKRSTTRDALDAGVDGIMTNYPDV
ITDVLNEAAYKKKFRVATYDDNPWVTFK
3D structure
PDB4rw5 Structural Insights into Substrate Binding of Brown Spider Venom Class II Phospholipases D.
ChainA
Resolution1.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A12 E32 D34 H48 G49 D53 D92 K94 W225 D228 N247
Catalytic site (residue number reindexed from 1) A11 E31 D33 H47 G48 D52 D91 K93 W224 D227 N246
Enzyme Commision number 4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E32 D34 D92 E31 D33 D91
BS02 OCA A E32 H48 D92 K94 S133 S167 W225 M245 E31 H47 D91 K93 S132 S166 W224 M244
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0006629 lipid metabolic process
GO:0016042 lipid catabolic process
GO:0031640 killing of cells of another organism
GO:0035821 modulation of process of another organism
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:4rw5, PDBe:4rw5, PDBj:4rw5
PDBsum4rw5
PubMed25961401
UniProtP0CE82|A1HB2_LOXIN Dermonecrotic toxin LiSicTox-alphaIA1bii (Fragment)

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