Structure of PDB 4rvh Chain A

Receptor sequence

>4rvhA (length=418) Species: 41951 (Streptomyces argillaceus) [Search protein sequence]

TARAVTTCRMCGAQDWQEVVDFGPVPLADSFLEPAASYDDEPRYPLAVVS
CRSCRLMSLTHVVDPEVLYRTYPYTTSDSETIKKHMGHVVAVCVERFGIP
EGSFVLEIGSNTGSQLKAFQNAGMRTLGIDPARNIAAVANERGIETLPEF
FSVDTAALVKKTHGTPQLVLGRHVFAHIDDVSAVAEGVRDLLGPDSLFAI
EVPYLVDMLERNEFDTIYHEHLSYIGVGSLVALFRRHGLRVVDVERLAVH
GGSILVFVGLDEGTRATAPVVEELIALEKERGLYEDATYERFARHVAEIT
AELTSMVRSLRAEGKRIAGYGAPAKGNTLLNVCGLTADDLEFCCDTTEFK
QGLVLPGTHIPVRSPEYAKTQAIDYYLLLAWNYGEEILAKEGPFLADGGR
FILPNPRPSIVPPGEHHH

3D structure

PDB

4rvh Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain.

Chain

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	C13 C16 C56 C59	C8 C11 C51 C54
BS02	SAH	A	Y74 Y77 T81 G114 N116 D135 P136 F155 F156 R177 H178 V179	Y69 Y72 T76 G109 N111 D130 P131 F150 F151 R172 H173 V174
BS03	3YN	A	Y77 Y79 H182 Y223 H226 P328 A329 K330 D350 T351 N387 Y388 K395	Y72 Y74 H177 Y218 H221 P323 A324 K325 D345 T346 N382 Y383 K390

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity
GO:0046872	metal ion binding

	Biological Process
GO:0032259	methylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:4rvh, PDBe:4rvh, PDBj:4rvh
PDBsum	4rvh
PubMed	25587924
UniProt	Q194Q4

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