Structure of PDB 4rv3 Chain A

Receptor sequence
>4rv3A (length=302) Species: 426430 (Staphylococcus aureus subsp. aureus str. Newman) [Search protein sequence]
DSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQDK
DYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLS
AYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNAN
PTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLN
LKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNS
TYNYASFINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDSN
KL
3D structure
PDB4rv3 Fluorinated Aromatic Amino Acids Distinguish Cation-pi Interactions from Membrane Insertion.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H30 D31 R67 H80 D281
Catalytic site (residue number reindexed from 1) H29 D30 R66 H79 D280
Enzyme Commision number 4.6.1.13: phosphatidylinositol diacylglycerol-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 INS A H30 R67 R166 D206 H29 R66 R165 D205
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4rv3, PDBe:4rv3, PDBj:4rv3
PDBsum4rv3
PubMed26092728
UniProtP45723|PLC_STAAE 1-phosphatidylinositol phosphodiesterase (Gene Name=plc)

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